CURRICULUM VITAE
LAWRENCE G. LEICHTMAN, M.D.

LAST UPDATED: June 20, 2010

NAME: Lawrence G. Leichtman, M.D.
OFFICE ADDRESS:
520 Jose St #11
Santa Fe, NM 87501
PHONE: (505) 467-8637

DATE AND PLACE OF BIRTH: July 30, 1947; Bronx, New York

MILITARY SERVICE:

Army Basic Training Fort Hood, Texas, 1969
Army Medical Corps Basic Training Fort Sam Houston, Texas, 1969
Army Combat Jump School, Fort Benning, Georgia, 1969
Commissioned 2nd Lieutenant U.S. Army, active, 1971
Commissioned Captain U.S. Army Reserve Medical Corps, 1981
OCS Fort Bragg, North Carolina, 1981
Promoted to Major
Served Joint Command for Military Services Desert Shield and Desert Storm, Norfolk, VA
Promoted to Lieutenant Colonel
Discharged Honorable December 1992

ETHNIC/RACIAL SELF-IDENTIFICATION (CHECK ONE)

  1. ___ American Indian or Alaskan Native
  2. ___ Asian or Pacific Islander
  3. ___ Black, not of Hispanic Origin
  4. ___ Mexican American or Chicano (Hispanic)
  5. ___ Puerto Rican (Hispanic)
  6. ___ Other Hispanic
  7. _X_ White, not of Hispanic Origin
  8. ___ Do not wish to respond
SCHOOL/HOSPITAL DATES DEGREE FIELD
UNDERGRADUATE DEGREE University of Texas 1965-69 BA
GRADUATE DEGREE University of Texas 1969-71 MA Psychology
Texas Tech University
School of Medicine		 1972-76 M.D.
INTERNSHIP Tulsa Medical College
University of Oklahoma, Tulsa		 1976-77
RESIDENCY Tulsa Medical College
University of Oklahoma, Tulsa		 1977-79
FELLOWSHIP/OTHER Tulsa Medical College - Clinical Genetics
University of Oklahoma, Tulsa		 1979-81

HOSPITAL STAFF MEMBERSHIPS:

Staff, Children's Medical Center, Tulsa, OK 1980-88
Staff, St. John's Medical Center, Tulsa, OK 1979-1988
Staff, St. Francis Hospital, Tulsa, OK 1979-1988
Staff, Hillcrest Medical Center, Tulsa, OK 1979-1988
Staff, Children's Hospital of the King's Daughters, 1988-Present
Staff, Norfolk General Hospital 1988-Present
Staff, Bayside Hospital 1990-Present
Staff, Leigh Memorial Hospital 1990-Present
Staff, DePaul Hospital 1988-1997
Consultant, Riverside Hospital 1988-Present
Consultant, Bayside Hospital 1988-Present
Consulting Staff, Virginia Beach General, 1988-Present
Consultant, Portsmouth Naval Hospital 1988-Present

LICENSURE (NUMBER/STATE/YEAR): #0101042384 VIRGINIA 1988

COMPLETED REQUIREMENTS FOR BOARD CERTIFICATION:
SPECIALTY: Boards YEAR: 1980
SPECIALTY: Sub-Specialty Boards YEAR: 1987
BOARD CERTIFICATION:
SPECIALTY: Pediatrics YEAR: 1980
SPECIALTY: Clinical Genetics YEAR: 1987

ACADEMIC POSITIONS (MOST CURRENT FIRST):

RANK INSTITUTION YEARS
Associate Professor Eastern Virginia Medical School 1988-1997
Assistant Professor University of Oklahoma 1978-88

PROFESSIONAL/HOSPITAL POSITIONS (MOST CURRENT FIRST):

Participant in Ceridase/Gaucher's Treatment Protocol
National Health Professional Advisory Committee, Work Group March of Dimes,
White Plains, NY 1/23 to 1/25, 1994.
Operation Smile, Research Board 1993-current
Board Member, Tidewater Perinatal Task Force, Perinatal Substance Abuse Subcommittee
Admissions Committee, Eastern Virginia Medical School 1992-1997
Reviewer, 1992 Grants Alzheimer's and Related Disease Research Award Fund
Board of Directors Member, Action for Prevention through 1994
Reviewer, Journal of Pediatrics
Reviewer, American Journal of Medical Genetics, John Opitz, MD, Editor, 1990-Present
Committee member, Genetic Services Committee, American Society of Human Genetics, 1990-1993
Health Professional Advisory Committee, March of Dimes, Virginia State Division-current 1993-1994
Health Professional Advisory Committee, March of Dimes, Tidewater Region-current Chairman 1991-1993
Health Professional Advisory Committee, March of Dimes, Tidewater Region-current Vice-President 1990-1991
Director, Division of Genetics, Department of Pediatrics, Eastern Virginia Medical School 1988-February 1994
Associate Professor, Eastern Virginia Medical School 1988
State of Oklahoma, Satellite Genetics Clinics
Medical Advisory Board, National Mucopolysaccharidosis Association
Medical Advisory Committee, Tulsa Lamaze Association
Council of Regional Genetics Networks, Reimbursement Task Force, Baltimore, Maryland 1986
Chairman, 3rd Party Payment Committee, Great Plains Clinical Genetics Network 1985-Present
Secretary, Pediatric Staff, St. Francis Hospital, Pediatric Department 1984
Fellow, Clinical Genetics, Children's Medical Center, July 1979-June 1981

TEACHING EXPERIENCE (BRIEFLY DESCRIBE COURSES TAUGHT, PROFESSIONAL LEVEL OF STUDENTS AND PERIODS OF TIME INVOLVED IN SUCH TEACHING):

1988-1997 4th Year Medical Students 10 per year
1989-Present 3rd Year Pediatric Residents 3 per year
1989-Present 3rd Year Pediatric Resident staff 5/year
1992-1997 Core Course in Human Genetics, 20 hours per year 1st year EVMS students
1993-1997 8 contact hours per week 1st and 3rd year medical students through Genetics' Clinic and Craniofacial Clinic
1993 Core Genetics' Education 1st year Medical Students EVMS, Teratology, Dysmorphology, Biochemical Genetics
1994 Core Genetics, Teratology, Dysmorphology, Biochemical Genetics, and Gene Therapy
1994-1997 Core Genetics' Instruction, Department of Surgery (8/25/95)
1994-1997 Lecturer in Bioethics of Genetics for Bioethics Course
1995- 1997 Neurogenetics for Neurology Residents (last lectures 8/29/95-9/5/95)
1995- 1997 Lectures in Dysmorphology and Teratolgy Department of Pathology

LECTURES AND PRESENTATIONS

1988-1997 Course Lecturer: Medical Genetics, Eastern Virginia Medical School
1988-1997 Course Lecturer: Medical Genetics, Riverside Hospital, OB/GYN Resident training program
1988-1997 Co Director of Monthly Genetics' lectures, OB/GYN/Peds, CHKD
1989 Presentation: David Smith Meeting, Madrid, Spain, "Ectodermal Dysplasia Cutis Aplasia, and Facial Dysmorphism in Mother and Daughter. A recognizable Autosomal Dominant Syndrome."
1989 Course Director: "Train the Trainer" Program in Genetics for State Health Department Nurses
1989 Dysmorphology Grand Rounds, Portsmouth Naval Hospital Pediatrics
1989 Grand Rounds, CHKD, The discovery of the Cystic Fibrosis Gene
1990 Meeting Director: "The New Genetics, Biotechnology and Bioethics"
1990 Presentation: Eastern Virginia Annual Family Practice Update, Hemoglobinopathy Screening
1990 Presentation: David Smith Dysmorphology Meeting, Lexington, KY, "Hemifacial Microsomia and DiGeorge Anomaly: How common is it?"
1990 Genetics in Surgical Practice, Sentara Norfolk General Hospital
1990 Grand Rounds Pediatrics, Riverside Hospital, Molecular Genetics in General Pediatrics
1991 Presentation: Virginia State Academy of Pediatrics, "Molecular Genetics in Pediatric Diagnosis and Therapy"
1991 Presentation: Anophthalmia, cleft lip/palate and CNS anomalies: A new syndrome? March of Dimes Birth Defects Meeting, Vancouver,
1991 Presentation: "Is Type A-I Diabetes Mellitus in pregnancy a teratogen?" David Smith Dysmorphology Meeting, San Bernandino, CA
1992 Invited Presentation: Gene Therapy in Pediatrics. Children's Health Systems and Peninsula Pediatric Society. Newport News, VA
1992 Invited Presentation: The Genetics of Muscular Dystrophy. "Neurologically Impaired Individuals Symposium", Richmond, VA
1992 Genetics in the 21st Century: Eastern Shore Health Association; Nassawadox, VA: Sponsored by March of Dimes
1993 The Genetics of Down Syndrome: Update, Tidewater Down Syndrome Support Group
1993 Progeria Syndromes: Tidewater Medical Transcriptionist Association
1993 Basic Genetics for Surgeons. Eastern Virginia Medical School, Department of Surgery
1993 Defects in Beta-oxidation of Fatty Acids: Virginia State Genetics Association
1993 Babies and You Genetics, Nags Head, NC: Sponsored by March of Dimes
1993 Genetics: The Basics for Health Care Providers: Resource Mothers of Tidewater
1993 "Are Cardio-Facio-Cutaneous Syndrome and Noonan Syndrome distinct: A case of a CFC offspring of a mother with Noonan Syndrome." David Smith Dysmorphology Society, Mont Tremblant, Quebec, Canada
1993 Neurofibromatosis Clinical Presentation. Eastern Regional Neurofibromatosis Conference, Norfolk, VA
1993 Genetics and Prenatal Care, March of Dimes
1993 Cardio-Facio-Cutaneous Syndrome an Evolving History, Virginia State Genetics' Meeting
1993 Genetics in the Public Interest, State of Virginia Conference for Public Health Nurses
1993 Perinatal Clinical Genetics, Tidewater Perinatal Nurses Association
1994 Genetics in Perinatal Medicine, Tidewater Perinatal Nurse's Association
1994 Genetics in Perinatal Medicine, DePaul Hospital Perinatal Nurses
1994 Genetics in Craniofacial Medicine, Hofheimer Hall
1994 Genetics for Plastic Surgeons, Operation Smile International Meeting, Sentara Norfolk General, Brickhouse Auditorium.
1994 Overgrowth Syndrome: A new entity and report of cases. David Smith Dysmorphology Meeting. Tampa, Florida. August, 1994
1995 Use of Piracetam in Down Syndrome. Is it a practical consideration? Tidewater Down Syndrome Support Group January 1995
1995 Babies and You Human Genetics for March of Dimes USAA, Canon Corporation Jan 1995
1995 Dysmorphology in Perinatal Medicine. Neonatal/Perinatal Nurses Association of Tidewater 2 lectures one at DePaul Hospital and one at Virginia Beach Graduate Center March and April 1995
1995 Bioethics in Molecular Genetics and Gene Therapy Joint meeting Virginia Perinatal Association and March of Dimes. October 5, 1995 Ft. Magruder Inn Williamsburg, VA
1995 The Role of Clinical Genetics in Pediatrics. Sentara Bayside Medical Staff Nov. 2. 1995
1996 Curbside Consultations Coordinator clinical Genetics Consultant to other clinical geneticists at March of Dimes Birth Defects and American College of Medical Genetics Meeting San Antonio, TX 3/11/96
1996 Biomedical Ethics in Genetics to SPARKS Gifted High School Association Virginia Beach Public Schools 50 students February
1996 Lecture in Genetics in Labor and Delivery for Portsmouth General Nursing Staff 20 staff February
1996 Genetics in Craniofacial Medicine Operation Smile Participant Training 40 Doctors May
1996 New Advances in Human Genetics Grand Rounds Virginia Beach General Hospital 50 Doctors May
1996 Targeted Nutritional Intervention in Down Syndrome. Tidewater Down syndrome Support Group 75 parents August
1996 A new syndrome of skeletal dysplasia with Robin sequence, radioulnar synostosis, flexion contractures and talipes equinovarus. Presented 10/1/96 David Smith Dysmorphology Meeting Lake Arrowhead, CA 125 participants physicians
1996 The Role of Dysmorphology and Genetics in the Craniofacial.. The Team Approach to Cleft and Cranifacial Anomalies: Recommended Parameters of Care. Williamsburg, VA 10/4/96 100 participants
1996 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Windsor, Ontario 120 participants 10 physicians, 10 nurses. October Sponsored by Ontario Down syndrome support group
1996 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. South Bend Indiana, 300 participants 20 physicians, 35 nurses, 20 educators. October Sponsored by Indiana and Western Michigan Down syndrome support groups
1996 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(4), physcial therapists(4) and physicians(7). Farmington New Mexico November 11
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(8), physical therapists(6), speech therapists(3), teachers(6), occupational therapists(5), physicians (7). St Louis MO March 14
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(2), PT(2), speech therapists(3), physicians(6). May 11 Cherry Hill, NJ
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(3), PT(6), speech therapists(1), physicians(5). May 12 Hazelton, PA
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(2), PT(3), speech therapists(2), physicians(2). May 18 Stockton, CA
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(8), PT(5), speech therapists(7), physicians(5). August 8, Scranton, PA
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(6), PT(15), speech therapists(5), physicians(20). September 29, Syracuse, NY
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 18 month study. Parents, nurses(8), PT(5), speech therapists(7), physicians(5). September 15, Scranton, PA
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 36 month study. Parents, nurses(20), PT(10), speech therapists(10), physicians(20). October 5, Syracuse, NY
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 36 month study. Parents, nurses(30), PT(5), speech therapists(10), physicians(40). November 10-11, London, England
1997 Targeted Nutritional Intervention in Down Syndrome. Report of an 36 month study. Parents, nurses(6), PT(15), speech therapists(10), physicians(5). December 5, South Bend, IN
1997 ODU Chance Program, The role of genetics in the management of adults with developmental disabilities. 2 lectures November and Decemebr, Department of Education
1998 ODU TOPS Program, The role of genetics in the management of adults with developmental disabilities. Department of Education
1998 Targeted Nutritional Intervention in Down Syndrome. Management Issues. Richmond Down Syndrome support group May 1998
1998 Targeted Nutritional Intervention in Down Syndrome. The science and results of 2 year study, Down syndrome support group of Soputhern New Jersey, June 1998
1998 Targeted Nutritional Intervention in Down Syndrome. The results of a 2 year study. The National Down Syndrome Congress, Dallas TX August 1998 1998
1998 Bioethics in Genetic Medicine. Rothermel Foundation New Bern, NC November 1, 1998
1999 Targeted Nutritional Intervention in Down Syndrome Orange County Down Syndrome Support Group, Los Angeles, CA
1999 Alternative Treatments in Down syndrome. Down syndrome Workshop American College of Medical Genetics. March, Miami, FL
1999 Targeted Nutritional Intervention in Down syndrome, a Pilot Study. University of Arkansas Medical School, Department of Pediatric Research, March, Little Rock
1999 Targeted Nutritional Intervention in Down Syndrome, Houston Down syndrome Association Nov
2000 New Developments in Genetics and their application to medical practice. Southern Regional Down Syndrome Association, Atlanta GA February
2000 Alternative treatments in Down syndrome, Southern Regional Down Syndrome Association
2000 Bioethics in Human Genetics in General Practice Sentara VB General Family Practice Rounds
2000 Targeted Nutritional Intervention and behavioral therapies in the treatment of Children and adults with Down syndrome. Sociedad Perinatal de Panama y America Central, Panama City Panama 09/2000

Media Representation:
1996 Nightline ABC Targeted Nutritional Intervention in Down Syndrome
1997 Ira Magaziner Radio Show, Philidelphia Metabolic Diseases and there treatment
1997 48 Hours CBS Targeted Nutritional Intervention in Down Syndrome
1997 BBC 1 London Targeted Nutritional Intervention in Down Syndrome and other Genetic Disorders
1997 WAFX Norfolk, VA Down Syndrome.
1998 Hearsay Radio Talk Show, WHRV, Norfolk, Down Syndrome
1998 Television Interview All 3 Network Stations Sarasota Florida April 1998
1998 WNOR Radio March of Dimes current Update and New Research
1999 Secretin in the treatment of Autism Virginian Pilot, March

MEMBERSHIP ON EVMS COMMITTEES:
Admissions Committee

HONORS AND AWARDS:
N/A

COMMUNITY SERVICE:

Medical Advisory Committee, Tulsa Lamaze Association
Health Professional Advisory Committee, March of Dimes Tidewater Region-current Vice-President 1990-91
Health Professional Advisory Committee, March of Dimes Tidewater Region-current Chairman 1991-93
Health Professional Advisory Committee, March of Dimes Virginia State Division- current 1993-96
Operation Smile Research Board 1993-1997

MEMBERSHIP ON LOCAL/NATIONAL COMMITTEES AND BOARDS (INDICATE OFFICE HELD):

Member Program Committee American College of Medical Genetics
Chairman of Health Professional Advisory Board State of Virginia March of Dimes
Chairman of Health Professional Advisory Committee for March of Dimes
Member Clinical Practice Committee, position on reimbursement and CPT coding committee of American College of Medical Genetics 1992-1994
Member Program Committee American College of Medical Genetics 1995-1999
Member Professional Practices Committee American College of Medical Genetics 1997-2001
Board Member Tidewater Perinatal Task Force Perinatal Substance Abuse Subcommittee
Board Member of Disability Rights State of Virginia, 1999-2002

MEMBERSHIP IN PROFESSIONAL SOCIETIES:

Fellow, American Academy of Pediatrics

Section on Genetics
Section on Computers in Medicine
Member, American Medical Association
Member, American Society of Human Genetics
Member, Mid-Atlantic Regional Genetics Network
Diplomate, American Board of Medical Genetics
Member, Society for Craniofacial Genetics
Member, Southern Society for Pediatric Research
American College of Medical Genetics-Charter Member
Member Program Committee 1995-1998 American College of Medical Genetics
Member, David Smith Dysmorphology Society
Member, European Society of Human Genetics

PLEASE ATTACH FULL BIBLIOGRAPHY. LIST AUTHORS, TITLE OR ARTICLES, JOURNAL NAME, YEAR, VOLUME, AND PAGE. SEPARATELY LIST ABSTRACTS, BOOKS, MONOGRAPHS ACCEPTED FOR PUBLICATION BUT NOT YET IN PRINT AND ARTICLES SUBMITTED BUT NOT YET ACCEPTED FOR PUBLICATION.

PRESENT FUNDED RESEARCH AND TRAINING GRANTS AND CONTRACTS:

PREVIOUS FUNDED RESEARCH AND TRAINING GRANTS AND CONTRACTS:
PRINCIPAL INVESTIGATORLawrence G. Leichtman, M.D.
TITLEAssociate Professor
PERIOD OF GRANTYearly
TOTAL AMOUNT OF AWARD$134.500
SOURCE OF FUNDINGState of Virginia

BIBLIOGRAPHY

Publications:
Journals

  1. Ayoub C, Pfeifer D, Leichtman L: Treatment of Infants with Non-organic Failure to Thrive. Child Abuse and Neglect 3:937-941.
  2. Say B, Barber N, Leichtman L: Ankylosis, Facial Anomalies and Pulmonary Hypoplasia Syndrome. Am J Dis Child 133: 1196-1197, 1979.
  3. Leichtman L, Say B, Barber N: Primary Pulmonary Hypoplasia and Arthrogryposis Multiplex Congenita (Letter). J Peds 96 1980.
  4. Leichtman L, Say B, Coldwell J: Patients in a Clinic for Children with Multiple Handicaps: A Retrospective Diagnostic Evaluation. South Med. J 73 (9): 1221,1980.
  5. Say B, Barber D, Leichtman L: The Gordon Syndrome (Letter). J. Med. Genet. 17 (5):405, 1980.
  6. Carpenter N, Leichtman L, Munshi G, Fullerton P, Say B: The Marker X Chromosome Among Families with and without Histories of X-Linked Mental Retardation. (Abstract). Am Soc Hum Genet, Sep, 1980.
  7. Leichtman L, Carpenter N, Stamper, Say B: An Infant with Ring 17 Chromosome and Unusual Dermatoglyphics, A New Syndrome? Med. Genet., October 1981.
  8. Carpenter N, Leichtman L, Say B: Fragile-X Linked Mental Retardation. Am J Dis Child, May, 1982, 136: 392-398.
  9. Leichtman L and Schooley K: Physical Abuse of a Pregnant Woman: A Possible Teratogen? Dysmorph and Clin Gen (1987) (1): 17-20.
  10. Ardinger H, Hanson J, Harrod M, Cohen M, Welch J, Young-Wee T, Sommer A, Goldberg R, Sprintzen R, Sidoti E, Leichtman L, Hoyme A: Further Delineation of the Weaver Syndrome. J of Peds 108: 2:228- 235, 1986.
  11. Leichtman L, Brown D, and Arnold H: Syndrome Identification Case Report. Arachnodactyly, Joint Laxity and Spondylolisthesis. Dysmorphology and Clinical Genetics, 1988 2(1): 13-15.
  12. Leichtman L: Ectopic Limbs. 1987 Number 2494 in ML Buyse, ed. Birth Defects Encyclopedia I.AR Liss, New York.
  13. Leichtman LG, Chaves E, Nowicki MJ, Charity L, Brothman AR: A unique case of partial Monosomy 22: Phenotypic and karyotypic description and comparison to a case of partial Trisomy 22 with the same break- point. Am Journal of Human Genetics 43: 3, 1988.
  14. Hommes FA, Brewster MA, Burton BK, Elsas LJ, Goldsmith BM, Hammond J, Kruckeberg WC, Leichtman LG, Lin KT, Martin RS, Matalon R, Naylor EW, O'Brien WE, Roe CR, Roesel AR, Shapira E, Taylor HA, Tedesco TA, Thompson JN, Tocci PM, Wilson WG: P roficiency Testing for Biochemical Genetics Laboratories: The First 10 Rounds of Testing. Am J Hum Genet 46: 1004-1005, 1990.
  15. Leichtman L, Newlin A, Leadem P: Ectodermal Dysplasia, Cutis Aplasia, and Facial Dysmorphism in Mother and Daughter: A Recognizable Autosomal Dominant Syndrome. Proceedings of the Greenwood Genetic Center Vol. 9, P96 1990.
  16. Leichtman L, Werner A, Bass WT, Smith D, Brothman AR: Apparent Occurrence of Opitz G Syndrome with Partial Duplication of Chromosome 5p. Am J Med Genet 40: 273-276 (1991).
  17. Leichtman LG, Strum D, Brothman A: Multiple Craniofacial anomalies associated with an interstitial deletion of chromosome 1(q21>q25). American Journal of Medical Genetics, 45: 6,677-678 (1993).
  18. Jaffer-Leichtman Syndrome: Inclusion in London Dysmorphology Database including CD ROM invited by editors. Publication date 1993.
  19. Leichtman LG: The combination of hemifacial microsomia and DiGeorge anomaly. How common is it? Proceedings of the Greenwood Clinic 10: 79-80, 1991.
  20. Leichtman L, Poley RJ, Rohn R, Solhaug M: Alagille Syndrome: Association of Rickets: Report of two cases. Submitted Southern Medical Journal 84 (10) 1205-1209 1991
  21. Leichtman LG, Wood B, Rohn R: Anophthalmia, Cleft lip/palate, Facial dysmorphism, and CNS anomalies and hypothalamic disorder in a newborn: A midline developmental field defect. Am J Med Genet, 50: 39-41 (1994).
  22. Leichtman LG: Are Cardio-Facio-Cutaneous Syndrome and Noonan Syndrome distinct: A case of CFC offspring of a mother with Noonan Syndrome. Proceedings of the Greenwood Clinic 12: 1993.
  23. Interstitial deletion of chromosome 1q21>q25 in POSSUM index laser disk 1993.
  24. Brothman AR, Newlin A, Phillips SE, Kinzie GQ, and Leichtman LG: Prenatal detection of an inverted X chromosome in a male. Clin Genet 44: 139-141.
  25. Leichtman LG: Are Cardio-Facio-Cutaneous Syndrome and Noonan Syndrome distinct: A case of CFC offspring of a mother with Noonan Syndrome. Clinical Dysmorphology 5, 61-64 (1996)
  26. Robin NH, Feldman GJ, Aaronson AL, Mitchell HF, Weksberg R, Leonard CO, Burton BK, Josephson KD, Laxova R , Aleck KA, Allanson JE, Guion-Almeida ML, Martin RA, Leichtman LG, Price RA, Opitz JM, Muenke M: Opitz syndrome is genetically heteroge nous, with one locus on Xp22 and a second locus on 22q11.2. Nature Genetics 11, 459-461 (1995)
  27. Leichtman, LG, Zackowski, JL, Storto, PD, Newlin, A.: Non-mosaic tetrasomy 9p in a liveborn infant with multiple congenital anomalies: Case report and comparison with trisomy 9p.Am.J.Med.Genet.. 63:434-437 (1996)
  28. Buckley, L.M., Bullaboy, CM, Leichtman, L, Marquez, M: Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother. Arthritis and Rheumatism 40:5:971-973(1997)

Submitted for Publication

  1. Greinwald, JH, Leichtman L, Simko E.J: Hereditary Thyrogolossal Duct Cysts. submitted to Archives of Ontolaryngological, Head ands Neck Surgery

In Press

  1. Crouch E, Leichtman L: Ophthalmologic abnormalities in a patient with Dubowitz Syndrome: A case report. Journal of Pediatic Ophthalmology and Strabismus

Book Chapters

  1. Leichtman LG, Burg FG, Ingelfinger JR, Wald ER, Palin RA: Eds. Hypoglycemia and Glycogen Storage Diseases in Gellis and Kagan's Current Pediatric Therapy, 15th Edition WB Saunders Philadelphia, Pennsylvania, 1995 .
  2. Leichtman LG, Burg FG, Ingelfinger JR, Wald ER, Palin RA: Eds. Hepatolenticular Degeneration in Gellis and Kagans Current Pediatric Therapy, 15th Edition, WB Saunders, Philadelphia, Pennsylvania 1995

Rescinded

  1. Moore RG, Leichtman LG: Unusual gynecologic malformations in Coffin-Siris Syndrome: A case report and review of the literature. Article Rescinded. Dysmorphology and Clinical Genetics.

RESEARCH

  1. Clinical research in the delineation of Birth Defects.
  2. Placental Mosaicism and Intrauterine Growth Retardation; pilot studies done, funding not yet available. This is a joint project with Maternal-Fetal Medicine and Stan Hoegerman of William and Mary University.
  3. Flunarazine in the treatment of Alternating Hemiplegia. Joint study with Matthew Frank, M.D. and Don Lewis, M.D.
  4. Gastrointestinal complications in Osteogenesis Imperfecta. Joint study with Ralph Moore, 2nd year Pediatric Resident CHKD Study Completed 1992.
  5. Standards for laboratory certification in amino acid and organic acid studies administered by Fritts Hommes, University of South Carolina.
  6. The use of computers in the diagnosis of Craniofacial abnormalities. Joint Project with John DiLiberti, M.D., Ph.D., Columbus Children's Hospital Genetics.
  7. Type A1 diabetes mellitus in pregnancy. Is it a teratogen? Funding applied March of Dimes and American Diabetes Association.
  8. International Database for complex cleft palate in collaboration with Howard Saal, M.D., University of Cincinnati Medical School. Funding applied through numerous private and public granting agencies. Current Database enrollees include: Murray J, U niversity of Iowa; Lipson T, Royal Alexandria Hospital for Children in Adelaide, Australia; Vilsher L, Sackler School of Medicine in Tel Aviv; Neidich J, Stanford University Medical Center; Bachman R, Kaiser Permanente. First samples have been sent an d process is now underway. Funding will be applied through Cleft Palate Craniofacial Association and Operation Smile International awaiting funding
  9. Use of Piracetam in Down Syndrome. International Cooperative Study with the University of Toronto and FDA. When applicable funding will be private and include study on the differential effects of aging in community- based versus institutionalized pat ients with Down Syndrome.
  10. Targeted Nutritional Intervention in Down Syndrome. The use of a multivitamin/digestive enzyme/amino acid/fatty acid supplement will be investigated using a double-blindedmethodology.Anticipated funding $630,000 for 2 year study privately funded.
  11. Cystathionine-beta-synthetase in Trisomy 21: Its function in the production of mental retardation and an approach to predicting severity of impairment in Trisomy 21 and a search for a selective inhibitor. Funding $87,000 from Trisomy 21 Research. Pr incipal Investigator David H. Swenson, PHD HH Dow Professor of Chemistry Saginaw Valley State University, Saginaw, MI .
  12. Ceresine in the Treatment of Chronic Lactic Acidosis. Joint Study with Cypros Pharmaceuticals and the FDA.

CME 1988-Present

1988 - American Society of Human Genetics, New Orleans, LA
1988 - Mid-Atlantic Regional Genetics Network, Baltimore, MD
1989 - Annual David Smith Dysmorphology Meeting, Madrid, Spain
1989 - Mid-Atlantic Regional Genetics Network, Baltimore, MD
1989 - American Society of Human Genetics, Baltimore, MD
1990 - The Child's Eye, Face and Brain, Baylor University, Houston, TX
1990 - Disorders in Fatty Acid Metabolism, Washington, DC
1990 - Annual David Smith Dysmorphology Meeting, Lexington, KY
1990 - American Society of Human Genetics, Cincinnati, OH
1991 - Virginia Academy of Pediatrics, State Meeting
1991 - March of Dimes Birth Defects Meeting, Vancouver, BC, Canada
1991 - David Smith Dysmorphology Meeting, San Bernardino, CA
1991 - Society for Craniofacial Genetics, Vancouver, BC
1991 - American Society of Human Genetics, Washington, DC
1992 - Neurologically Impaired Individuals-Symposium, Richmond, VA
1992 - American Society of Human Genetics, San Francisco, CA
1993 - Mid-Atlantic Regional Genetics Network; Annual Meeting, Washington, DC
1993 - Operation Smile, Gaza Mission
1993 - David Smith Dysmorphology Society Meeting, Mont Tremblant, Quebec, Canada
1994 - U.S. Health Professionals: An Educational Role in Developing Countries, Norfolk, VA Sponsored by Operation Smile International.
1994 - March of Dimes Birth Defects Meeting and American College of Human Genetics, Orlando, FL
1994 - David Smith Dysmorphology Society Meeting, Tampa, Florida
1994 - American Society of Human Genetics Meeting, Montreal, Canada
1994 - Ongoing Neurology Rounds CHKD q. Friday A.M.
1994 - Grand Rounds CHKD q. Thursday A.M.
1995- Bioethics in Molecular Genetics and Gene Therapy Joint meeting Virginia Perinatal Association and March of Dimes. October 5, 1995 Ft. Magruder Inn Williamsburg, VA
1996- March of Dimes Birth Defects Meeting and American College of Human Genetics, San Antonio, TX
1996-David Smith Dysmorphology Society Meeting Lake Arrowhead, CA
1996-The Team Approach to Cleft and Craniofacial Anomalies: Recommended Parameters of Care. Williamsburg, VA
1997-American Society of Human Genetics Meeting, Baltimore, MD
1998-March of Dimes Birth Defects Meeting and American College of Human Genetics, Los Angeles, CA March, 1998
1998-National Down Syndrome Congress Dallas, TX August, 1998
1998-American Society of Human Genetics Meeting Denver, CO
1999-March of Dimes Birth Defects Meeting and American College of Medical Genetics Miami, FL
1999-American Society of Human Genetics Meeting San Francisco, CA October 19-23
1999-National Down Syndrome Society Meeting Pittsburgh, PA August
1999-Journal reading over 200 hours
1999-Online research for proposed NIH grant in Targeted Nutritional Intervention 100 hours
2000- 15 hours Atlanta Down syndrome Association meeting
2000- 40 hours Level I CME credit online from WebMD
2000- 15 hours Sociedad Perinatal de Panama y America Central. Panama City Panama September 2000